Undergraduate Honors Thesis

Abstract

• This work describes the total synthesis and characterization of an asymmetrically substituted scyllo-inositol. Starting from a cheap an abundant α-D-methylglucoside, generation of the product was achieved in nine steps. This synthesis capitalized on a Ferrier II reaction which generated the inositol core, followed by a selective reduction, protection, and stereochemical inversion to convert the initial myo-inositol to the desired scyllo-inositol. This asymmetric scyllo-inositol will be used in the future as the head of axinelloside A.

Creator

• Rodriguez, Jacob

Date Awarded

• 2018-01-01

Academic Affiliation

• Chemistry

Advisor

• Walczak, Maciej

Committee Member

• Olwin, Bradley
• Parson, Robert

Granting Institution

• University of Colorado Boulder

Subject

• asymmetric synthesis
• natural product
• scyllo-inositol
• telomerase
• total synthesis

Última modificación

• 2019-12-02

Resource Type

• Undergraduate Honors Thesis

Declaración de derechos

• In Copyright

Language

• English [eng]

Relaciones

En Collection:

• Arts and Sciences Honors Program

Elementos

Miniatura	Título	Fecha de subida	Visibilidad	Acciones
	synthesisOfAsymmetricallySubstitutedScylloInositol.pdf	2019-11-30	Público	Descargar