Graduate Thesis Or Dissertation
Elucidating the Genetic Architecture of Sleep Health and Associations with External Correlates: A Behavioral and Statistical Genetics Analysis Public Deposited
- Abstract
Sleep is a fundamental benchmark of mental, physical and behavioral health. The construct of sleep health is at the crux of a shift in the field aimed to focus less specifically on disordered sleep, and more on sleep as a whole continuum. Sleep health has many social, environmental and biological determinants, some that can be behaviorally modified, as well as a host of negative health outcomes associated with sleep. For that reason, sleep health is thought to be a modifiable health behavior that may aid in prevention or mitigation for certain diseases and disorders, such as psychiatric disorders. Indeed, sleep health has been proposed to be a transdiagnostic risk factor for psychiatric disorders. However, several major gaps in the literature loom. First, there is no clear consensus on how to best operationalize sleep health, such as with a summary score or as independent variables. Second, the broad scale genomic architecture of sleep health remains poorly understood. Third, associations between sleep health and psychiatric disorders are well accepted, but knowledge of causality remains indistinct.
Here, we synthesized three projects that contribute considerable knowledge to the sleep health literature. Using Genomic Structural Equation Modelling, we tested several latent genetic structures of sleep health and computed three multivariate genome-wide association studies on latent genetic sleep health factors. After, we performed bioinformatic analyses to assess the shared and unique genetic underpinnings between sleep health domains. Finally, we triangulated across co-twin control and Mendelian Randomization methods to test for patterns consistent with causality across sleep health and psychiatric domains.
Collectively our results partially support the idea of sleep health being a transdiagnostic risk factor for psychiatric disorders, but parsimonious models revealed specific sleep traits are much more reliably related to specific psychiatric disorders than others. Sleep health is more than just the linear sum of all its domains, and it would be misguided to lump all sleep traits together and assume they predict all psychiatric disorders the same. Overall, these findings indicate sleep health has a unique and important role as a potential modifiable health behavior for psychiatric disorders.
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- Date Issued
- 2023-04-11
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- 2024-01-16
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Morrison_colorado_0051E_18166.pdf | 2023-12-15 | Public | Download |
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Thesis_Approval_Form.pdf | 2023-12-15 | Public | Download |
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sleepGWAS_supplement.xlsx | 2023-12-15 | Public | Download |