Article

Abstract

• Exposure to stressors disrupts homeostasis and results in the release of stress hormones including glucocorticoids, epinepherine and norepinepherine. Interestingly, stress also has profound affects on microglia, which are tissue-resident macrophages in the brain parenchyma. Microglia express a diverse array of receptors, which also allows them to respond to stress hormones derived from peripheral as well as central sources. Here, we review studies of how exposure to acute and chronic stressors alters the immunophenotype and function of microglia. Further, we examine a causal for stress hormones in these effects of stress on microglia. We propose that microglia serve as immunosensors of the stress response, which puts them in the unique position to sense and respond rapidly to alterations in homeostasis and integrate the neural response to threats.

Creator

• Fonken, Laura K.
• Frank, Matthew G.
• Watkins, Linda R.
• Maier, Steven F.

Academic Affiliation

• Psychology and Neuroscience
• Center for Neuroscience

Journal Title

• Seminars in Cell & Developmental Biology

Journal Volume

• 94

Subject

• stress
• neuroinflammation
• innate immunity
• microglia

Última modificación

• 2020-10-28

Resource Type

• Postprint

Declaración de derechos

• In Copyright

DOI

•  https://dx.doi.org/10.1016/j.semcdb.2019.01.001

ISSN

• 1096-3634
• 1084-9521

Language

• English [eng]

Relaciones

Elementos

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