Article

Abstract

• Focused ultrasound with microbubbles promises unprecedented advantages for blood-brain barrier disruption over existing intracranial drug delivery methods, as well as a significant number of tunable parameters that affect its safety and efficacy. This review provides an engineering perspective on the state-of-the-art of the technology, considering the mechanism of action, effects of microbubble properties, ultrasound parameters and physiological variables, as well as safety and potential therapeutic applications. Emphasis is placed on the use of unified parameters, such as microbubble volume dose (

Creator

• Borden, Mark A
• Song, Kang-Ho
• Harvey, Brandon K

Date Issued

• 2018-01-01

Academic Affiliation

• Mechanical Engineering

Journal Title

• Theranostics

Journal Issue/Number

• 16

Journal Volume

• 8

File Extent

• 4393-4408

Zuletzt geändert

• 2019-12-06

Identifier

• PubMed ID: 30214628

Resource Type

• Article

Urheberrechts-Erklärung

• In Copyright

DOI

•  https://doi.org/10.7150/thno.26869

ISSN

• 1838-7640

Language

• English [eng]

License

• Creative Commons BY-NC Attribution-NonCommercial 4.0

Beziehungen

Artikel

Miniaturansicht	Titel	Datum Hochgeladen	Sichtbarkeit	Aktionen
	stateOfTheArtOfMicrobubbleAssistedBloodBrainBarrierDisr.pdf	2019-12-06	Öffentlichkeit	Herunterladen