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Microbubble gas volume: A unifying dose parameter in blood-brain barrier opening by focused ultrasound. Público Deposited

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https://scholar.colorado.edu/concern/articles/bn999746f
Abstract
  • Focused ultrasound with microbubbles is being developed to transiently, locally and noninvasively open the blood-brain barrier (BBB) for improved pharmaceutical delivery. Prior work has demonstrated that, for a given concentration dose, microbubble size affects both the intravascular circulation persistence and extent of BBB opening. When matched to gas volume dose, however, the circulation half-life was found to be independent of microbubble size. In order to determine whether this holds true for BBB opening as well, we independently measured the effects of microbubble size (2 vs. 6 µm diameter) and concentration, covering a range of overlapping gas volume doses (1-40 µL/kg). We first demonstrated precise targeting and a linear dose-response of Evans Blue dye extravasation to the rat striatum for a set of constant microbubble and ultrasound parameters. We found that dye extravasation increased linearly with gas volume dose, with data points from both microbubble sizes collapsing to a single line. A linear trend was observed for both the initial sonication (R
Creator
Date Issued
  • 2017-01-01
Academic Affiliation
Journal Title
Journal Issue/Number
  • 1
Journal Volume
  • 7
File Extent
  • 144-152
Subject
Última modificación
  • 2019-12-06
Identifier
  • PubMed ID: 28042323
Resource Type
Declaración de derechos
DOI
ISSN
  • 1838-7640
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