Article

 

Signaling Networks among Stem Cell Precursors, Transit-Amplifying Progenitors, and their Niche in Developing Hair Follicles. Público Deposited

https://scholar.colorado.edu/concern/articles/kw52j881s
Abstract
  • The hair follicle (HF) is a complex miniorgan that serves as an ideal model system to study stem cell (SC) interactions with the niche during growth and regeneration. Dermal papilla (DP) cells are required for SC activation during the adult hair cycle, but signal exchange between niche and SC precursors/transit-amplifying cell (TAC) progenitors that regulates HF morphogenetic growth is largely unknown. Here we use six transgenic reporters to isolate 14 major skin and HF cell populations. With next-generation RNA sequencing, we characterize their transcriptomes and define unique molecular signatures. SC precursors, TACs, and the DP niche express a plethora of ligands and receptors. Signaling interaction network analysis reveals a bird's-eye view of pathways implicated in epithelial-mesenchymal interactions. Using a systematic tissue-wide approach, this work provides a comprehensive platform, linked to an interactive online database, to identify and further explore the SC/TAC/niche crosstalk regulating HF growth.
Creator
Date Issued
  • 2016-03-29
Academic Affiliation
Journal Title
Journal Issue/Number
  • 12
Journal Volume
  • 14
File Extent
  • 3001-3018
Subject
Última modificación
  • 2019-12-05
Identifier
  • PubMed ID: 27009580
Resource Type
Declaración de derechos
DOI
ISSN
  • 2211-1247
Language

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