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Changing Polygenic Penetrance on Phenotypes in the 20(th) Century Among Adults in the US Population. Pubblico Deposited

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https://scholar.colorado.edu/concern/articles/jw827c30n
Abstract
  • This study evaluates changes in genetic penetrance-defined as the association between an additive polygenic score and its associated phenotype-across birth cohorts. Situating our analysis within recent historical trends in the U.S., we show that, while height and BMI show increasing genotypic penetrance over the course of 20(th) Century, education and heart disease show declining genotypic effects. Meanwhile, we find genotypic penetrance to be historically stable with respect to depression. Our findings help inform our understanding of how the genetic and environmental landscape of American society has changed over the past century, and have implications for research which models gene-environment (GxE) interactions, as well as polygenic score calculations in consortia studies that include multiple birth cohorts.
Creator
Date Issued
  • 2016-07-26
Academic Affiliation
Journal Title
Journal Volume
  • 6
File Extent
  • 30348-30348
Subject
Ultima modifica
  • 2019-12-05
Identifier
  • PubMed ID: 27456657
Resource Type
Dichiarazione dei diritti
DOI
ISSN
  • 2045-2322
Language

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