Article

 

Spaceflight Activates Lipotoxic Pathways in Mouse Liver. Público Deposited

https://scholar.colorado.edu/concern/articles/8g84mm89v
Abstract
  • Spaceflight affects numerous organ systems in the body, leading to metabolic dysfunction that may have long-term consequences. Microgravity-induced alterations in liver metabolism, particularly with respect to lipids, remain largely unexplored. Here we utilize a novel systems biology approach, combining metabolomics and transcriptomics with advanced Raman microscopy, to investigate altered hepatic lipid metabolism in mice following short duration spaceflight. Mice flown aboard Space Transportation System -135, the last Shuttle mission, lose weight but redistribute lipids, particularly to the liver. Intriguingly, spaceflight mice lose retinol from lipid droplets. Both mRNA and metabolite changes suggest the retinol loss is linked to activation of PPARα-mediated pathways and potentially to hepatic stellate cell activation, both of which may be coincident with increased bile acids and early signs of liver injury. Although the 13-day flight duration is too short for frank fibrosis to develop, the retinol loss plus changes in markers of extracellular matrix remodeling raise the concern that longer duration exposure to the space environment may result in progressive liver damage, increasing the risk for nonalcoholic fatty liver disease.
Creator
Date Issued
  • 2016-01-01
Academic Affiliation
Journal Title
Journal Issue/Number
  • 4
Journal Volume
  • 11
File Extent
  • 0152877-0152877
Subject
Última modificación
  • 2019-12-06
Identifier
  • PubMed ID: 27097220
Resource Type
Declaración de derechos
DOI
ISSN
  • 1932-6203
Language

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