Fifty one patients who were subjected to at least an hour of surgery were chosen for this study. Twenty nine of these were carried on thiopentone-nitrous oxide anesthesia. Seven of the twenty nine had secobarbital for induction. Twenty two were carried on pethidine-nitrous oxide anesthesia. In seventeen cases of the twenty two, initial narcosis was achieved with thiopentone. The waking time was then determined. The end point was considered as the time when the patient with his eyes closed could tell correctly when simultaneous light touch was made on the cheek and the contralateral hand. It was found that with the ages and anesthetic times for both groups, comparable, the patients who were carried on thiopentone-nitrous oxide anesthesia woke up later than those who were carried on pethidine-nitrous oxide anesthesia. Another observation made was that all of the seven patients who had no complaints of pain at the reaction time belonged to the pethidinenitrous oxide group.
Aquino, Teresita Dychitan, "Comparison Between Thiopentone-Nitrous Oxide and Pethidine-Nitrous Oxide Anesthesia With Respect to Reaction Time" (1954). University Libraries Digitized Theses 189x-20xx. 62.