Article

 

State-of-the-art of microbubble-assisted blood-brain barrier disruption. Public Deposited

https://scholar.colorado.edu/concern/articles/df65v865d
Abstract
  • Focused ultrasound with microbubbles promises unprecedented advantages for blood-brain barrier disruption over existing intracranial drug delivery methods, as well as a significant number of tunable parameters that affect its safety and efficacy. This review provides an engineering perspective on the state-of-the-art of the technology, considering the mechanism of action, effects of microbubble properties, ultrasound parameters and physiological variables, as well as safety and potential therapeutic applications. Emphasis is placed on the use of unified parameters, such as microbubble volume dose (
Creator
Date Issued
  • 2018-01-01
Academic Affiliation
Journal Title
Journal Issue/Number
  • 16
Journal Volume
  • 8
File Extent
  • 4393-4408
Last Modified
  • 2019-12-06
Identifier
  • PubMed ID: 30214628
Resource Type
Rights Statement
DOI
ISSN
  • 1838-7640
Language
License

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