Document Type

Article

Publication Date

1-1-2018

Publication Title

Theranostics

ISSN

1838-7640

Volume

8

Issue

16

First Page

4393

Last Page

4408

DOI

https://doi.org/10.7150/thno.26869

PubMed ID

30214628

Abstract

Focused ultrasound with microbubbles promises unprecedented advantages for blood-brain barrier disruption over existing intracranial drug delivery methods, as well as a significant number of tunable parameters that affect its safety and efficacy. This review provides an engineering perspective on the state-of-the-art of the technology, considering the mechanism of action, effects of microbubble properties, ultrasound parameters and physiological variables, as well as safety and potential therapeutic applications. Emphasis is placed on the use of unified parameters, such as microbubble volume dose (

Creative Commons License

Creative Commons Attribution-Noncommercial 4.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial 4.0 License

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