Article
State-of-the-art of microbubble-assisted blood-brain barrier disruption. Public Deposited
https://scholar.colorado.edu/concern/articles/df65v865d
- Abstract
- Focused ultrasound with microbubbles promises unprecedented advantages for blood-brain barrier disruption over existing intracranial drug delivery methods, as well as a significant number of tunable parameters that affect its safety and efficacy. This review provides an engineering perspective on the state-of-the-art of the technology, considering the mechanism of action, effects of microbubble properties, ultrasound parameters and physiological variables, as well as safety and potential therapeutic applications. Emphasis is placed on the use of unified parameters, such as microbubble volume dose (
- Creator
- Date Issued
- 2018-01-01
- Academic Affiliation
- Journal Title
- Journal Issue/Number
- 16
- Journal Volume
- 8
- File Extent
- 4393-4408
- Last Modified
- 2019-12-06
- Identifier
- PubMed ID: 30214628
- Resource Type
- Rights Statement
- DOI
- ISSN
- 1838-7640
- Language
- License
Relationships
Items
Thumbnail | Title | Date Uploaded | Visibility | Actions |
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stateOfTheArtOfMicrobubbleAssistedBloodBrainBarrierDisr.pdf | 2019-12-06 | Public | Download |