Document Type

Article

Publication Date

12-1-2017

Publication Title

Biomedical Optics Express

ISSN

2156-7085

Volume

8

Issue

12

First Page

5412

Last Page

5426

DOI

https://doi.org/10.1364/BOE.8.005412

PubMed ID

29296477

Abstract

Laser scanners are an integral part of high resolution biomedical imaging systems such as confocal or 2-photon excitation (2PE) microscopes. In this work, we demonstrate the utility of electrowetting on dielectric (EWOD) prisms as a lateral laser-scanning element integrated in a conventional 2PE microscope. To the best of our knowledge, this is the first such demonstration for EWOD prisms. EWOD devices provide a transmissive, low power consuming, and compact alternative to conventional adaptive optics, and hence this technology has tremendous potential. We demonstrate 2PE microscope imaging of cultured mouse hippocampal neurons with a FOV of 130 × 130 μm

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