Biomedical Optics Express
Laser scanners are an integral part of high resolution biomedical imaging systems such as confocal or 2-photon excitation (2PE) microscopes. In this work, we demonstrate the utility of electrowetting on dielectric (EWOD) prisms as a lateral laser-scanning element integrated in a conventional 2PE microscope. To the best of our knowledge, this is the first such demonstration for EWOD prisms. EWOD devices provide a transmissive, low power consuming, and compact alternative to conventional adaptive optics, and hence this technology has tremendous potential. We demonstrate 2PE microscope imaging of cultured mouse hippocampal neurons with a FOV of 130 × 130 μm
Supekar, Omkar D; Ozbay, Baris N; Zohrabi, Mo; Nystrom, Philip D; Futia, Gregory L; Restrepo, Diego; Gibson, Emily A; Gopinath, Juliet T; and Bright, Victor M, "Two-photon laser scanning microscopy with electrowetting-based prism scanning." (2017). Mechanical Engineering Faculty Contributions. 27.