Document Type

Article

Publication Date

2-28-2018

Publication Title

Nucleic Acids Research

ISSN

1362-4962

Volume

46

Issue

4

First Page

1756

Last Page

1776

DOI

https://doi.org/10.1093/nar/gkx1225

PubMed ID

29240919

Abstract

Histone deacetylase inhibitors (HDACIs) are known to alter gene expression by both up- and down-regulation of protein-coding genes in normal and cancer cells. However, the exact regulatory mechanisms of action remain uncharacterized. Here we investigated genome wide dose-dependent epigenetic and transcriptome changes in response to HDACI largazole in a transformed and a non-transformed cell line. Exposure to low nanomolar largazole concentrations (

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