Nucleic Acids Research
Histone deacetylase inhibitors (HDACIs) are known to alter gene expression by both up- and down-regulation of protein-coding genes in normal and cancer cells. However, the exact regulatory mechanisms of action remain uncharacterized. Here we investigated genome wide dose-dependent epigenetic and transcriptome changes in response to HDACI largazole in a transformed and a non-transformed cell line. Exposure to low nanomolar largazole concentrations (
Sanchez, Gilson J; Richmond, Phillip A; Bunker, Eric N; Karman, Samuel S; Azofeifa, Joseph; Garnett, Aaron T; Xu, Quanbin; Wheeler, Graycen E; Toomey, Cathryn M; Zhang, Qinghong; Dowell, Robin D; and Liu, Xuedong, "Genome-wide dose-dependent inhibition of histone deacetylases studies reveal their roles in enhancer remodeling and suppression of oncogenic super-enhancers." (2018). Molecular, Cellular, and Developmental Biology Faculty Contributions. 52.