Article

 

Genome-wide dose-dependent inhibition of histone deacetylases studies reveal their roles in enhancer remodeling and suppression of oncogenic super-enhancers. Public Deposited

https://scholar.colorado.edu/concern/articles/k643b179x
Abstract
  • Histone deacetylase inhibitors (HDACIs) are known to alter gene expression by both up- and down-regulation of protein-coding genes in normal and cancer cells. However, the exact regulatory mechanisms of action remain uncharacterized. Here we investigated genome wide dose-dependent epigenetic and transcriptome changes in response to HDACI largazole in a transformed and a non-transformed cell line. Exposure to low nanomolar largazole concentrations (
Creator
Date Issued
  • 2018-02-28
Academic Affiliation
Journal Title
Journal Issue/Number
  • 4
Journal Volume
  • 46
File Extent
  • 1756-1776
Publisher
Last Modified
  • 2019-12-05
Identifier
  • PubMed ID: 29240919
Resource Type
Rights Statement
DOI
ISSN
  • 1362-4962
Language

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