Article
Genome-wide dose-dependent inhibition of histone deacetylases studies reveal their roles in enhancer remodeling and suppression of oncogenic super-enhancers. Public Deposited
https://scholar.colorado.edu/concern/articles/k643b179x
- Abstract
- Histone deacetylase inhibitors (HDACIs) are known to alter gene expression by both up- and down-regulation of protein-coding genes in normal and cancer cells. However, the exact regulatory mechanisms of action remain uncharacterized. Here we investigated genome wide dose-dependent epigenetic and transcriptome changes in response to HDACI largazole in a transformed and a non-transformed cell line. Exposure to low nanomolar largazole concentrations (
- Creator
- Date Issued
- 2018-02-28
- Academic Affiliation
- Journal Title
- Journal Issue/Number
- 4
- Journal Volume
- 46
- File Extent
- 1756-1776
- Publisher
- Last Modified
- 2019-12-05
- Identifier
- PubMed ID: 29240919
- Resource Type
- Rights Statement
- DOI
- ISSN
- 1362-4962
- Language
Relationships
Items
Thumbnail | Title | Date Uploaded | Visibility | Actions |
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genomeWideDoseDependentInhibitionOfHistoneDeacetylasesStu.pdf | 2019-12-05 | Public | Download |