Article

 

Nuclear roles for cilia-associated proteins. Public Deposited

https://scholar.colorado.edu/concern/articles/cn69m481p
Abstract
  • Cilia appear to be derived, evolutionarily, from structures present in the ancestral (pre-ciliary) eukaryote, such as microtubule-based vesicle trafficking and chromosome segregation systems. Experimental observations suggest that the ciliary gate, the molecular complex that mediates the selective molecular movement between cytoplasmic and ciliary compartments, shares features with nuclear pores. Our hypothesis is that this shared transport machinery is at least partially responsible for the observation that a number of ciliary and ciliogenesis-associated proteins are found within nuclei where they play roles in the regulation of gene expression, DNA repair, and nuclear import and export. Recognizing the potential for such nuclear roles is critical when considering the phenotypic effects that arise from the mutational modification of ciliary proteins.
Creator
Date Issued
  • 2017-01-01
Academic Affiliation
Journal Title
Journal Volume
  • 6
File Extent
  • 8-8
Last Modified
  • 2019-12-05
Identifier
  • PubMed ID: 28560031
Resource Type
Rights Statement
DOI
ISSN
  • 2046-2530
Language
License

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