Editors

Koji Tamura

Document Type

Article

Publication Date

3-23-2017

Publication Title

Life

ISSN

2075-1729

Volume

7

Issue

2

DOI

https://doi.org/10.3390/life7020013

PubMed ID

28333103

Abstract

A significant part of the genetic code likely originated via a chemical interaction, which should be experimentally verifiable. One possible verification relates bound amino acids (or perhaps their activated congeners) and ribonucleotide sequences within cognate RNA binding sites. To introduce this interaction, I first summarize how amino acids function as targets for RNA binding. Then the experimental method for selecting relevant RNA binding sites is characterized. The selection method's characteristics are related to the investigation of the RNA binding site model treated at the outset. Finally, real binding sites from selection and also from extant natural RNAs (for example, the

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