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Submissions from 2018

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Idiopathic Scoliosis Families Highlight Actin-Based and Microtubule-Based Cellular Projections and Extracellular Matrix in Disease Etiology., Erin E Baschal, Elizabeth A Terhune, Cambria I Wethey, Robin M Baschal, Kandice D Robinson, Melissa T Cuevas, Shreyash Pradhan, Brittan S Sutphin, Matthew R G Taylor, Katherine Gowan, Chad G Pearson, Lee A Niswander, Kenneth L Jones, and Nancy H Miller

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The placenta goes viral: Retroviruses control gene expression in pregnancy., Edward B Chuong

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Striated muscle gene therapy for the treatment of lipoprotein lipase deficiency., Katherine E Gadek, Hong Wang, Monica N Hall, Mitchell Sungello, Andrew Libby, Drew MacLaskey, Robert H Eckel, and Bradley B Olwin

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Peer Instruction., Jennifer K Knight and Cynthia J Brame

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Synonymous mutations make dramatic contributions to fitness when growth is limited by a weak-link enzyme., JohnCarlo Kristofich, Andrew B Morgenthaler, Wallis R Kinney, Christopher C Ebmeier, Daniel J Snyder, William M Old, Vaughn S Cooper, and Shelley D Copley

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Species-specific vulnerability of RanBP2 shaped the evolution of SIV as it transmitted in African apes., Nicholas R Meyerson, Cody J Warren, Daniel A S A Vieira, Felipe Diaz-Griferro, and Sara L Sawyer

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The small things can matter., Norman R Pace

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Intratumoral heterogeneity of endogenous tumor cell invasive behavior in human glioblastoma., Jonathon J Parker, Peter Canoll, Lee Niswander, B K Kleinschmidt-DeMasters, Kara Foshay, and Allen Waziri

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Muscle stem cell dysfunction impairs muscle regeneration in a mouse model of Down syndrome., Bradley Pawlikowski, Nicole Dalla Betta, Tiffany Elston, Darian A Williams, and Bradley B Olwin

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A Faculty Professional Development Model That Improves Student Learning, Encourages Active-Learning Instructional Practices, and Works for Faculty at Multiple Institutions., Karen N Pelletreau, Jennifer K Knight, Paula P Lemons, Jill S McCourt, John E Merrill, Ross H Nehm, Luanna B Prevost, Mark Urban-Lurain, and Michelle K Smith

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A cell-based infection assay identifies efflux pump modulators that reduce bacterial intracellular load., Abigail L Reens, Amy L Crooks, Chih-Chia Su, Toni A Nagy, David L Reens, Jessica D Podoll, Madeline E Edwards, Edward W Yu, and Corrella S Detweiler

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Control of yeast retrotransposons mediated through nucleoporin evolution., Paul A Rowley, Kurt Patterson, Suzanne B Sandmeyer, and Sara L Sawyer

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miR-MaGiC improves quantification accuracy for small RNA-seq., Pamela H Russell, Brian Vestal, Wen Shi, Pratyaydipta D Rudra, Robin Dowell, Richard Radcliffe, Laura Saba, and Katerina Kechris

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Genome-wide dose-dependent inhibition of histone deacetylases studies reveal their roles in enhancer remodeling and suppression of oncogenic super-enhancers., Gilson J Sanchez, Phillip A Richmond, Eric N Bunker, Samuel S Karman, Joseph Azofeifa, Aaron T Garnett, Quanbin Xu, Graycen E Wheeler, Cathryn M Toomey, Qinghong Zhang, Robin D Dowell, and Xuedong Liu

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Kat2a and Kat2b Acetyltransferase Activity Regulates Craniofacial Cartilage and Bone Differentiation in Zebrafish and Mice., Rwik Sen, Sofia A Pezoa, Lomeli Carpio Shull, Laura Hernandez-Lagunas, Lee A Niswander, and Kristin Bruk Artinger

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Dengue viruses cleave STING in humans but not in nonhuman primates, their presumed natural reservoir., Alex C Stabell, Nicholas R Meyerson, Rebekah C Gullberg, Alison R Gilchrist, Kristofor J Webb, William M Old, Rushika Perera, and Sara L Sawyer

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EcoEvo-MAPS: An Ecology and Evolution Assessment for Introductory through Advanced Undergraduates., Mindi M Summers, Brian A Couch, Jennifer K Knight, Sara E Brownell, Alison J Crowe, Katharine Semsar, Christian D Wright, and Michelle K Smith

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Cellular plasticity, caspases and autophagy; that which does not kill us, well, makes us different., Tin Tin Su

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Detecting Differential Transcription Factor Activity from ATAC-Seq Data., Ignacio J Tripodi, Mary A Allen, and Robin D Dowell

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Ionizing radiation induces stem cell-like properties in a caspase-dependent manner in Drosophila., Shilpi Verghese and Tin Tin Su

Submissions from 2017

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Identification of the primary peptide contaminant that inhibits fibrillation and toxicity in synthetic amyloid-β42., Daniel J Adams, Travis G Nemkov, John P Mayer, William M Old, and Michael H B Stowell

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Discriminating between HuR and TTP binding sites using the k-spectrum kernel method., Shweta Bhandare, Debra S Goldberg, and Robin Dowell

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Diagnostic of students' misconceptions using the Biological Concepts Instrument (BCI): A method for conducting an educational needs assessment., Annie Champagne Queloz, Michael W Klymkowsky, Elsbeth Stern, Ernst Hafen, and Katja Köhler

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Live Cell Imaging Reveals pH Oscillations in Saccharomyces cerevisiae During Metabolic Transitions., Benjamin J T Dodd and Joel M Kralj

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Measurement Instrument for Scientific Teaching (MIST): A Tool to Measure the Frequencies of Research-Based Teaching Practices in Undergraduate Science Courses., Mary F Durham, Jennifer K Knight, and Brian A Couch

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Sophisticated lessons from simple organisms: appreciating the value of curiosity-driven research., Robert J Duronio, Patrick H O'Farrell, Greenfield Sluder, and Tin Tin Su

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Human TFIIH Kinase CDK7 Regulates Transcription-Associated Chromatin Modifications., Christopher C Ebmeier, Benjamin Erickson, Benjamin L Allen, Mary A Allen, Hyunmin Kim, Nova Fong, Jeremy R Jacobsen, Kaiwei Liang, Ali Shilatifard, Robin D Dowell, William M Old, David L Bentley, and Dylan J Taatjes

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TSPAN12 Is a Norrin Co-receptor that Amplifies Frizzled4 Ligand Selectivity and Signaling., Maria B Lai, Chi Zhang, Jianli Shi, Verity Johnson, Lavan Khandan, John McVey, Michael W Klymkowsky, Zhe Chen, and Harald J Junge

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The Histone Methyltransferase Ash1l is Required for Epidermal Homeostasis in Mice., Gang Li, Zhisheng Ye, Cheng Shi, Ling Sun, Min Han, Yuan Zhuang, Tian Xu, Shimin Zhao, and Xiaohui Wu

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Nuclear roles for cilia-associated proteins., Tristan D McClure-Begley and Michael W Klymkowsky

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What Motivates Biology Instructors to Engage and Persist in Teaching Professional Development?, Jill S McCourt, Tessa C Andrews, Jennifer K Knight, John E Merrill, Ross H Nehm, Karen N Pelletreau, Luanna B Prevost, Michelle K Smith, Mark Urban-Lurain, and Paula P Lemons

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Force-activated DNA substrates for probing individual proteins interacting with single-stranded DNA., Stephen R Okoniewski, Lyle Uyetake, and Thomas T Perkins

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A vitamin-B2-sensing mechanism that regulates gut protease activity to impact animal's food behavior and growth., Bin Qi, Marina Kniazeva, and Min Han

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Model based heritability scores for high-throughput sequencing data., Pratyaydipta Rudra, W Jenny Shi, Brian Vestal, Pamela H Russell, Aaron Odell, Robin D Dowell, Richard A Radcliffe, Laura M Saba, and Katerina Kechris

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Using Pre-Assessment and In-Class Questions to Change Student Understanding of Molecular Movements., J Shi, Jennifer K Knight, Hyonho Chun, Nancy A Guild, and Jennifer M Martin

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STAT, Wingless, and Nurf-38 determine the accuracy of regeneration after radiation damage in Drosophila., Shilpi Verghese and Tin Tin Su

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The Genetic Code and RNA-Amino Acid Affinities., Michael Yarus

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RNA Binding Protein Vigilin Collaborates with miRNAs To Regulate Gene Expression for, Rebecca A Zabinsky, Brett M Weum, Mingxue Cui, and Min Han

Submissions from 2016

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Col4a1 mutations cause progressive retinal neovascular defects and retinopathy., Marcel V Alavi, Mao Mao, Bradley T Pawlikowski, Manana Kvezereli, Jacque L Duncan, Richard T Libby, Simon W M John, and Douglas B Gould

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Crossing the Threshold: Bringing Biological Variation to the Foreground., Janet M Batzli, Jennifer K Knight, Laurel M Hartley, April Cordero Maskiewicz, and Elizabeth A Desy

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Sequence-dependent nanometer-scale conformational dynamics of individual RecBCD-DNA complexes., Ashley R Carter, Maasa H Seaberg, Hsiu-Fang Fan, Gang Sun, Christopher J Wilds, Hung-Wen Li, and Thomas T Perkins

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Targeted mRNA Decay by RNA Binding Protein AUF1 Regulates Adult Muscle Stem Cell Fate, Promoting Skeletal Muscle Integrity., Devon M Chenette, Adam B Cadwallader, Tiffany L Antwine, Lauren C Larkin, Jinhua Wang, Bradley B Olwin, and Robert J Schneider

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Two novel MYH7 proline substitutions cause Laing Distal Myopathy-like phenotypes with variable expressivity and neck extensor contracture., Miora Feinstein-Linial, Massimo Buvoli, Ada Buvoli, Menachem Sadeh, Ron Dabby, Rachel Straussberg, Ilan Shelef, Daniel Dayan, Leslie Anne Leinwand, and Ohad S Birk

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Two novel MYH7 proline substitutions cause Laing Distal Myopathy-like phenotypes with variable expressivity and neck extensor contracture., Miora Feinstein-Linial, Massimo Buvoli, Ada Buvoli, Menachem Sadeh, Ron Dabby, Rachel Straussberg, Ilan Shelef, Daniel Dayan, Leslie Anne Leinwand, and Ohad S Birk

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Two novel MYH7 proline substitutions cause Laing Distal Myopathy-like phenotypes with variable expressivity and neck extensor contracture., Miora Feinstein-Linial, Massimo Buvoli, Ada Buvoli, Menachem Sadeh, Ron Dabby, Rachel Straussberg, Ilan Shelef, Daniel Dayan, Leslie Anne Leinwand, and Ohad S Birk

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Computer Simulations Support a Morphological Contribution to BDNF Enhancement of Action Potential Generation., Domenico F Galati, Brian G Hiester, and Kevin R Jones

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3D Architecture of the Trypanosoma brucei Flagella Connector, a Mobile Transmembrane Junction., Johanna L Höög, Sylvain Lacomble, Cedric Bouchet-Marquis, Laura Briggs, Kristin Park, Andreas Hoenger, and Keith Gull

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Netrin1/DCC signaling promotes neuronal migration in the dorsal spinal cord., Harald J Junge, Andrea R Yung, Lisa V Goodrich, and Zhe Chen

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The Design and Transformation of Biofundamentals: A Nonsurvey Introductory Evolutionary and Molecular Biology Course., Michael W Klymkowsky, Jeremy D Rentsch, Emina Begovic, and Melanie M Cooper

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Group Random Call Can Positively Affect Student In-Class Clicker Discussions, Joel K. Knight, Sarah B. Wise, and Scott Sieke

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NOVA regulates Dcc alternative splicing during neuronal migration and axon guidance in the spinal cord., Janelle C Leggere, Yuhki Saito, Robert B Darnell, Marc Tessier-Lavigne, Harald J Junge, and Zhe Chen

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Oxidative Stress Impairs Cell Death by Repressing the Nuclease Activity of Mitochondrial Endonuclease G., Jason L J Lin, Akihisa Nakagawa, Riley Skeen-Gaar, Wei-Zen Yang, Pei Zhao, Zhe Zhang, Xiao Ge, Shohei Mitani, Ding Xue, and Hanna S Yuan

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A Brief History of Research on Mitotic Mechanisms., J Richard McIntosh and Thomas Hays

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The Apoptotic Engulfment Machinery Regulates Axonal Degeneration in C. elegans Neurons., Annika L A Nichols, Ellen Meelkop, Casey Linton, Rosina Giordano-Santini, Robert K Sullivan, Alessandra Donato, Cara Nolan, David H Hall, Ding Xue, Brent Neumann, and Massimo A Hilliard

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Murine Polyomavirus Cell Surface Receptors Activate Distinct Signaling Pathways Required for Infection., Samantha D O'Hara and Robert L Garcea

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Loss of niche-satellite cell interactions in syndecan-3 null mice alters muscle progenitor cell homeostasis improving muscle regeneration., Addolorata Pisconti, Glen B Banks, Farshad Babaeijandaghi, Nicole Dalla Betta, Fabio M V Rossi, Jeffrey S Chamberlain, and Bradley B Olwin

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Immunizing against Anogenital Cancer: HPV Vaccines., Cloe S Pogoda, Richard B S Roden, and Robert L Garcea

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Identification of Mediator Kinase Substrates in Human Cells using Cortistatin A and Quantitative Phosphoproteomics, Zachary C. Poss, Christopher C. Ebmeier, Aaron T. Odell, Anupong Tangpeerachaikul, Thomas Lee, Henry E. Pelish, Matthew D. Shair, Robin D. Dowell, William M. Old, and Dylan J. Taatjes

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Using Student Writing and Lexical Analysis to Reveal Student Thinking about the Role of Stop Codons in the Central Dogma., Luanna B Prevost, Michelle K Smith, and Jennifer K Knight

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A trans-acting Variant within the Transcription Factor RIM101 Interacts with Genetic Background to Determine its Regulatory Capacity., Timothy Read, Phillip A Richmond, and Robin D Dowell

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Signaling Networks among Stem Cell Precursors, Transit-Amplifying Progenitors, and their Niche in Developing Hair Follicles., Amélie Rezza, Zichen Wang, Rachel Sennett, Wenlian Qiao, Dongmei Wang, Nicholas Heitman, Ka Wai Mok, Carlos Clavel, Rui Yi, Peter Zandstra, Avi Ma'ayan, and Michael Rendl

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XRN1 Is a Species-Specific Virus Restriction Factor in Yeasts., Paul A Rowley, Brandon Ho, Sarah Bushong, Arlen Johnson, and Sara L Sawyer

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NOVA2-mediated RNA regulation is required for axonal pathfinding during development., Yuhki Saito, Soledad Miranda-Rottmann, Matteo Ruggiu, Christopher Y Park, John J Fak, Ru Zhong, Jeremy S Duncan, Brian A Fabella, Harald J Junge, Zhe Chen, Roberto Araya, Bernd Fritzsch, A J Hudspeth, and Robert B Darnell

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Non-human Primate Schlafen11 Inhibits Production of Both Host and Viral Proteins., Alex C Stabell, John Hawkins, Manqing Li, Xia Gao, Michael David, William H Press, and Sara L Sawyer

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Factors Influencing Bacterial Diversity and Community Composition in Municipal Drinking Waters in the Ohio River Basin, USA., Lee F Stanish, Natalie M Hull, Charles E Robertson, J Kirk Harris, Mark J Stevens, John R Spear, and Norman R Pace

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Factors Influencing Bacterial Diversity and Community Composition in Municipal Drinking Waters in the Ohio River Basin, USA., Lee F Stanish, Natalie M Hull, Charles E Robertson, J Kirk Harris, Mark J Stevens, John R Spear, and Norman R Pace

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Survey of cryptic unstable transcripts in yeast., Jessica M Vera and Robin D Dowell

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Drosophila Wnt and STAT Define Apoptosis-Resistant Epithelial Cells for Tissue Regeneration after Irradiation., Shilpi Verghese and Tin Tin Su

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Disruption of the Golgi protein Otg1 gene causes defective hormone secretion and aberrant glucose homeostasis in mice., Guangxue Wang, Rongbo Li, Ying Yang, Liang Cai, Sheng Ding, Tian Xu, Min Han, and Xiaohui Wu

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At the mercy of viruses., Claus O Wilke and Sara L Sawyer

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Generation of a Mouse Full-length Balancer with Versatile Cassette-shuttling Selection Strategy., Zhisheng Ye, Lei Sun, Rongbo Li, Min Han, Yuan Zhuang, Xiaohui Wu, and Tian Xu

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Defects in Stratum Corneum Desquamation Are the Predominant Effect of Impaired ABCA12 Function in a Novel Mouse Model of Harlequin Ichthyosis., Lei Zhang, Michael Ferreyros, Weiguo Feng, Melanie Hupe, Debra A Crumrine, Jiang Chen, Peter M Elias, Walter M Holleran, Lee Niswander, Daniel Hohl, Trevor Williams, Enrique C Torchia, and Dennis R Roop

Submissions from 2015

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miR-30 family microRNAs regulate myogenic differentiation and provide negative feedback on the microRNA pathway., Martin G Guess, Kristen K B Barthel, Brooke C Harrison, and Leslie A Leinwand

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miR-30 family microRNAs regulate myogenic differentiation and provide negative feedback on the microRNA pathway., Martin G Guess, Kristen K B Barthel, Brooke C Harrison, and Leslie A Leinwand

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Dendritic targeting of short and long 3' UTR BDNF mRNA is regulated by BDNF or NT-3 and distinct sets of RNA-binding proteins., Annalisa Vicario, Andrea Colliva, Antonia Ratti, Laetitia Davidovic, Gabriele Baj, Łukasz Gricman, Claudia Colombrita, Alberto Pallavicini, Kevin R Jones, Barbara Bardoni, and Enrico Tongiorgi

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Dendritic targeting of short and long 3' UTR BDNF mRNA is regulated by BDNF or NT-3 and distinct sets of RNA-binding proteins., Annalisa Vicario, Andrea Colliva, Antonia Ratti, Laetitia Davidovic, Gabriele Baj, Łukasz Gricman, Claudia Colombrita, Alberto Pallavicini, Kevin R Jones, Barbara Bardoni, and Enrico Tongiorgi