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BACKGROUND: Evidence suggests that childhood near-roadway air pollution (NRAP) exposures contribute to increased body mass index (BMI); however, effects of NRAP exposure during the vulnerable periods including in utero and first year of life have yet to be established. In this study, we examined whether exposure to elevated concentrations of NRAP during in utero and/or first year of life increase childhood BMI growth.
METHODS: Participants in the Children's Health Study enrolled from 2002 to 2003 with annual visits over a four-year period and who changed residences before study entry were included (n = 2318). Annual height and weight were measured and lifetime residential NRAP exposures including in utero and first year of life periods were estimated by nitrogen oxides (NO
RESULTS: A two-standard deviation difference in first year of life near-road freeway NO
CONCLUSIONS: Higher exposure to early life NRAP increased the rate of change of childhood BMI and resulted in a higher attained BMI at age 10 years that were independent of later childhood exposures. These findings suggest that elevated early life NRAP exposures contribute to increased obesity risk in children.
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Kim, Jeniffer S; Alderete, Tanya L; Chen, Zhanghua; Lurmann, Fred; Rappaport, Ed; Habre, Rima; Berhane, Kiros; and Gilliland, Frank D, "Longitudinal associations of in utero and early life near-roadway air pollution with trajectories of childhood body mass index." (2018). Integrative Physiology Faculty Contributions. 28.