Multiple lines of evidence implicate brain serotonin (5-hydroxytryptamine; 5-HT) system dysfunction in the pathophysiology of stressor-related and anxiety disorders. Here we investigate the influence of constitutively deficient 5-HT synthesis on stressor-related anxiety-like behaviors using Tryptophan hydroxylase 2 (Tph2) mutant mice. Functional assessment of c-Fos after associated foot shock, electrophysiological recordings of GABAergic synaptic transmission, differential expression of the Slc6a4 gene in serotonergic neurons were combined with locomotor and anxiety-like measurements in different contextual settings. Our findings indicate that constitutive Tph2 inactivation and consequential lack of 5-HT synthesis in Tph2 null mutant mice (Tph2
Waider, J; Popp, S; Lange, M D; Kern, R; Kolter, J F; Kobler, J; Donner, N C; Lowe, K R; Malzbender, J H; Brazell, C J; Arnold, M R; Aboagye, B; Schmitt-Böhrer, A; Lowry, C A; Pape, H C; and Lesch, K P, "Genetically driven brain serotonin deficiency facilitates panic-like escape behavior in mice." (2017). Integrative Physiology Faculty Contributions. 24.