Article

Abstract

• Multiple lines of evidence implicate brain serotonin (5-hydroxytryptamine; 5-HT) system dysfunction in the pathophysiology of stressor-related and anxiety disorders. Here we investigate the influence of constitutively deficient 5-HT synthesis on stressor-related anxiety-like behaviors using Tryptophan hydroxylase 2 (Tph2) mutant mice. Functional assessment of c-Fos after associated foot shock, electrophysiological recordings of GABAergic synaptic transmission, differential expression of the Slc6a4 gene in serotonergic neurons were combined with locomotor and anxiety-like measurements in different contextual settings. Our findings indicate that constitutive Tph2 inactivation and consequential lack of 5-HT synthesis in Tph2 null mutant mice (Tph2

Creator

• Waider, J
• Pape, H C
• Malzbender, J H
• Popp, S
• Lesch, K P
• Lowe, K R
• Kolter, J F
• Donner, N C
• Lange, M D
• Kern, R
• Brazell, C J
• Aboagye, B
• Kobler, J
• Lowry, C A
• Arnold, M R
• Schmitt-Böhrer, A

Date Issued

• 2017-10-03

Academic Affiliation

• Integrative Physiology

Journal Title

• Translational Psychiatry

Journal Issue/Number

• 10

Journal Volume

• 7

File Extent

• 1246-1246

Subject

• Male
• gamma-Aminobutyric Acid
• Mice
• Inhibitory Postsynaptic Potentials
• Knockout
• Raphe Nuclei
• Escape Reaction
• Anxiety
• Panic Disorder
• Electroshock
• Fear
• Amygdala
• Tryptophan Hydroxylase
• Serotonin
• Agoraphobia
• Serotonin Plasma Membrane Transport Proteins
• Animals

Last Modified

• 2019-12-05

Identifier

• PubMed ID: 28972592

Resource Type

• Article

Rights Statement

• In Copyright

DOI

•  https://doi.org/10.1038/tp.2017.209

ISSN

• 2158-3188

Language

• English [eng]

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