Undergraduate Honors Theses

Thesis Defended

Spring 2012

Document Type




First Advisor

Prof. Robert Sievers


Vaccination has been used to prevent diseases since the early 1800s.Throughout the history of vaccination, attention has only been paid to the type of virus that can be administered instead of the method of vaccination. Traditional needle-dependent vaccination requires sanitation and refrigeration which is not available in developing countries such as India, where viruses such as the human papillomavirus (HPV) are very prevalent. The goal of this study was to develop a sublingual wafer formulation that is robust and heat-stable. The sublingual wafer delivery method is expected to lower the cost of vaccination because of the ease of transportation and storage. Dry powder vaccine formulations were prepared using the Sievers et al patented Carbon Dioxide Assisted Nebulization with a Bubble Dryer (CAN- BD) drying process. Excipients commonly used in the pharmaceutical industry for oral tablet formation were tested for wafer formation with the CAN-BD processed protein powder. Desired wafer properties were tested, i.e. binding capabilities, target dissociation time.