Type of Thesis
Molecular, Cellular, & Developmental Biology
Dr. Linda Watkins
Dr. Kevin Jones
Dr. Monika Fleshner
Clinical research studies show that chronic pain is a prevalent, difficult affliction to manage. The most common management for chronic pain is opioids, which research is showing to paradoxically induce persistent, worsened pain states as well as potentially having negative effects on memory. The necessity for understanding chronic pain and drug management options is apparent, and research is aiming to do just that. Exercise is one potential preventative measure or post hoc treatment possibility for chronic pain, as abundant research has shown. Knowledge of the interactions between exercise, morphine dosing, and peripheral nerve injury is nonexistent. As such, we desired to investigate whether prior to injury voluntary exercise could prevent paradoxical hyperalgesia experienced after morphine regimen cessation. We also desired to investigate these same parameters with relation to memory.
Plattner, Nathan, "Prior voluntary wheel running prevents memory deficits and enhanced neuropathic pain presenting after morphine dosing ceases" (2018). Undergraduate Honors Theses. 1598.
Animal Experimentation and Research Commons, Behavioral Neurobiology Commons, Medicinal Chemistry and Pharmaceutics Commons, Molecular and Cellular Neuroscience Commons, Nervous System Diseases Commons, Other Immunology and Infectious Disease Commons, Pathological Conditions, Signs and Symptoms Commons, Pharmacology Commons