Undergraduate Honors Theses

Thesis Defended

Spring 2018

Document Type


Type of Thesis

Departmental Honors


Molecular, Cellular, & Developmental Biology

First Advisor

Dr. Linda Watkins

Second Advisor

Dr. Kevin Jones

Third Advisor

Dr. Monika Fleshner


Clinical research studies show that chronic pain is a prevalent, difficult affliction to manage. The most common management for chronic pain is opioids, which research is showing to paradoxically induce persistent, worsened pain states as well as potentially having negative effects on memory. The necessity for understanding chronic pain and drug management options is apparent, and research is aiming to do just that. Exercise is one potential preventative measure or post hoc treatment possibility for chronic pain, as abundant research has shown. Knowledge of the interactions between exercise, morphine dosing, and peripheral nerve injury is nonexistent. As such, we desired to investigate whether prior to injury voluntary exercise could prevent paradoxical hyperalgesia experienced after morphine regimen cessation. We also desired to investigate these same parameters with relation to memory.