Article

 

Phylogenetic factorization of compositional data yields lineage-level associations in microbiome datasets. Public Deposited

https://scholar.colorado.edu/concern/articles/4q77fr886
Abstract
  • Marker gene sequencing of microbial communities has generated big datasets of microbial relative abundances varying across environmental conditions, sample sites and treatments. These data often come with putative phylogenies, providing unique opportunities to investigate how shared evolutionary history affects microbial abundance patterns. Here, we present a method to identify the phylogenetic factors driving patterns in microbial community composition. We use the method, "phylofactorization," to re-analyze datasets from the human body and soil microbial communities, demonstrating how phylofactorization is a dimensionality-reducing tool, an ordination-visualization tool, and an inferential tool for identifying edges in the phylogeny along which putative functional ecological traits may have arisen.
Creator
Date Issued
  • 2017-01-01
Academic Affiliation
Journal Title
Journal Volume
  • 5
File Extent
  • 2969-2969
Subject
Last Modified
  • 2019-12-05
Identifier
  • PubMed ID: 28289558
Resource Type
Rights Statement
DOI
ISSN
  • 2167-8359
Language
License

Relationships

Items