Graduate Thesis Or Dissertation

 

Diazepam Effects on Anxiety-related Defensive Behavior of High and Low Open-Field Activity Inbred Mouse Strains Public Deposited

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https://scholar.colorado.edu/concern/graduate_thesis_or_dissertations/dv13zv468
Abstract
  • Open-field activity is a commonly used measure of anxiety-related behavior in rodents. The inbred High and Low Activity strains of mice, selected for extreme differences in open-field activity, have been used as a genetic model of anxiety-related behaviors. The goal of this study was to determine if treatment of adult male and female High Activity (low anxiety) and Low Activity (high anxiety) mice with Diazepam, a benzodiazepine commonly prescribed to treat anxiety disorders in humans, lead to decreases in anxiety-like behavioral responses as assessed in the open-field test and elevated plus-maze. The only anxiolytic response observed was in the High Activity animals, with more entries into the open arms of the elevated plus-maze, like common mouse strains. Lack of response to Diazepam suggests the Low Activity animals are not displaying classic conflict anxiety-like behavior, and instead may be displaying unconditioned fear-related behaviors, such as freezing behaviors, when exposed to novelty.

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  • 2022-04-13
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  • 2022-07-11
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