Graduate Thesis Or Dissertation

 

Thermal Tissue Fusion of Arteries: Methods, Mechanisms, & Mechanics Público Deposited

https://scholar.colorado.edu/concern/graduate_thesis_or_dissertations/cc08hf88n
Abstract
  • Tissue fusion is a method of joining biological tissues using heat and pressure. Tissue fusion has been used effectively for the ligation of blood vessels during surgery, which is performed by clamping the blood vessel closed and then applying heat to the tissue. During tissue fusion, the structural proteins in the tissue denature, water is vaporized, and a bond is formed between the tissues. The mechanics and mechanisms of the tissue fusion bond are still unknown and to this end, experiments were developed to elucidate the crucial parameters necessary to fuse tissue and measure the mechanical response of the bond. The strategy to understand direct heat arterial tissue fusion was a three-pronged approach: i) experimental measurement of the conditions in the tissue during fusion, ii) experimental measurement of tissue fusion strength, and iii) modeling of heat transfer and water dependent tissue properties with comparison to experimental temperature data. The results from this body of work suggest that fusion strength is a function of time, temperature, applied force, and tissue water content. The experimental data also correlates increased fusion strength with increased water loss during fusion. This work supports the hypothesis that water driven out of the tissue enables bonding of the extra-cellular matrix proteins.
Creator
Date Issued
  • 2013
Academic Affiliation
Advisor
Committee Member
Degree Grantor
Commencement Year
Subject
Última modificação
  • 2019-11-14
Resource Type
Declaração de direitos
Language

Relações

Itens