Data Set

Abstract

• Abstract from the manuscript: Breath analysis enables rapid, non-invasive diagnostics, as well as long-term monitoring, of human health through the identification and quantification of exhaled biomarkers. Here, for the first time, we demonstrate the remarkable capabilities of mid-infrared (mid-IR) cavity-enhanced direct frequency comb spectroscopy (CE-DFCS) applied to breath analysis. We simultaneously detect and monitor as a function of time four breath biomarkers - CH3OH, CH4, H2O and HDO - as well as illustrating the feasibility of detecting at least six more (H2CO, C2H6, OCS, C2H4, CS2 and NH3) without modifications to the experimental apparatus. We achieve ultra-high detection sensitivity at the parts-per-trillion level. This is made possible by the combination of the broadband spectral coverage of a frequency comb, the high spectral resolution afforded by the individual comb teeth, and the sensitivity enhancement resulting from a high-finesse cavity. Exploiting recent advances in frequency comb, optical coating, and photodetector technologies, we can access a large variety of biomarkers with strong carbon-hydrogen bond spectral signatures in the mid-IR.

Creator

• Qizhong Liang; Ya-Chu Chan; P. Bryan Changala; David J. Nesbitt; Jun Ye; Jutta Toscano

Academic Affiliation

• Physics
• JILA
• Chemistry

Publisher

• University of Colorado - Boulder

Last Modified

• 2021-09-03

Resource Type

• Data Set

Rights Statement

• In Copyright

DOI

•  https://doi.org/hdxe-2m79

Language

• English [eng]

Citation

• Qizhong Liang; Ya-Chu Chan; P. Bryan Changala; David J. Nesbitt; Jun Ye; Jutta Toscano. (2021). Ultra-sensitive multi-species spectroscopic breath analysis for real-time health monitoring and diagnostics [Data set]. University of Colorado Boulder. https://doi.org/10.25810/HDXE-2M79

Relationships

Items

Thumbnail	Title	Date Uploaded	Visibility	Actions
	BreathAnalysisData.zip	2021-08-19	Public	Download
	README_v2.txt	2021-09-02	Public	Download