Article

Abstract

• Stents are a widely-used device to treat a variety of cardiovascular diseases. The purpose of this review is to explore the application of regenerative medicine principles into current and future stent designs. This review will cover regeneration-relevant approaches emerging in the current research landscape of stent technology. Regenerative stent technologies include surface engineering of stents with cell secretomes, cell-capture coatings, mimics of endothelial products, surface topography, endothelial growth factors or cell-adhesive peptides, as well as design of bioresorable materials for temporary stent support. These technologies are comparatively analyzed in terms of their regenerative effects, therapeutic effects and challenges faced; their benefits and risks are weighed up for suggestions about future stent developments. This review highlights two unique regenerative features of stent technologies: selective regeneration, which is to selectively grow endothelial cells on a stent but inhibit the proliferation and migration of smooth muscle cells, and stent-assisted regeneration of ischemic tissue injury.

   

Creator

• Selvakumar, Prakash Parthiban
• Johnson, Richard
• Tan, Wei
• Rafuse, Michael Scott

Date Issued

• 2022

Academic Affiliation

• Mechanical Engineering

Journal Title

• Frontiers in Bioengineering and Biotechnology

Journal Volume

• 10

Last Modified

• 2024-07-01

Resource Type

• Article

Rights Statement

• In Copyright

DOI

•  https://doi.org/10.3389/fbioe.2022.826807

ISSN

• 2296-4185

Language

• English [eng]

License

• Creative Commons BY Attribution 4.0 International

Relationships

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