Article

 

Glial contributions to visceral pain: implications for disease etiology and the female predominance of persistent pain. 公开 Deposited

https://scholar.colorado.edu/concern/articles/gf06g3296
Abstract
  • In the central nervous system, bidirectional signaling between glial cells and neurons ('neuroimmune communication') facilitates the development of persistent pain. Spinal glia can contribute to heightened pain states by a prolonged release of neurokine signals that sensitize adjacent centrally projecting neurons. Although many persistent pain conditions are disproportionately common in females, whether specific neuroimmune mechanisms lead to this increased susceptibility remains unclear. This review summarizes the major known contributions of glia and neuroimmune interactions in pain, which has been determined principally in male rodents and in the context of somatic pain conditions. It is then postulated that studying neuroimmune interactions involved in pain attributed to visceral diseases common to females may offer a more suitable avenue for investigating unique mechanisms involved in female pain. Further, we discuss the potential for primed spinal glia and subsequent neurogenic inflammation as a contributing factor in the development of peripheral inflammation, therefore, representing a predisposing factor for females in developing a high percentage of such persistent pain conditions.
Creator
Date Issued
  • 2016-09-13
Academic Affiliation
Journal Title
Journal Issue/Number
  • 9
Journal Volume
  • 6
File Extent
  • 888-888
Subject
最新修改
  • 2019-12-05
Identifier
  • PubMed ID: 27622932
Resource Type
权利声明
DOI
ISSN
  • 2158-3188
Language

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