Underrepresented Populations at the Archaic Introgression Frontier
Public Deposited- Abstract
Recent advancements in the recovery of ancient genomes have yielded high-coverage sequences for two archaic human species: Neanderthals and Denisovans. Perhaps more surprisingly, direct comparisons of archaic and modern human genomes have revealed a complex landscape of admixture between both archaic species and modern humans (Browning et al., 2018; Villanea and Schraiber, 2019). While we call these regions of the human genome “archaically introgressed”, they are functional contributors to the living human gene pool, affecting our health and fitness. For Neanderthals in particular, early archaic ancestry maps focused on modern Eurasians, as hundreds of genomes from Europe and East Asia were readily available from the 1000 Genomes Project (see Sankararaman et al., 2014; Vernot and Akey, 2014). Coupled with the geographic distribution of Neanderthal archaeological sites, which are largely located in Europe, this created a strong impression to the larger public that individuals of European descent, in particular, carried archaic genomic elements, which coincided with a larger interest in commodifying archaic ancestry by personalized genomic companies—as evidenced by 23 and Me incorporating a report of Neanderthal ancestry into their mainline product.
- Creator
- Date Issued
- 2022
- Academic Affiliation
- Journal Title
- Journal Volume
- 13
- Last Modified
- 2023-07-26
- Resource Type
- Rights Statement
- License
- DOI
- ISSN
- 1664-8021
- Language
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fgene-13-821170.pdf | 2023-07-26 | Public | Download |