Article
Lifestyle and psychosocial associations with cognition at the cusp of midlife using twins and siblings Public Deposited
- Abstract
Introduction: This study investigates the relationship between cognitive functioning and 59 modifiable and intrinsic factors at the cusp of midlife.
Methods: We analyzed data from 1221 participants in the Colorado Adoption/Twin Study of Lifespan behavioral development and cognitive aging (CATSLife; Mage = 33.20, %Female = 52.74). We assessed the impact of 59 factors on cognitive functioning using regularized regression and co-twin control models, controlling for earlier-life cognitive functioning and gray matter volume.
Results: Eight robust factors were identified, including education attainment, cognitive complexity, purpose-in-life, and smoking status. Twins reporting higher levels of cognitive complexity and purpose-in-life showed better cognitive performance than their cotwin, while smoking was negatively associated. Using meta-analytically derived effect size threshold, we additionally identified that twins experiencing more financial difficulty tend to perform less well compared with their cotwin.
Discussion: The findings highlight the early midlife link between cognitive functioning and lifestyle/psychological factors, beyond prior cognitive performance, brain status, genetic and familial confounders. Our results further highlight the potential of established adulthood as a crucial window for dementia prevention interventions targeting lifestyle and psychosocial factors.
Highlights: Cog complexity(+), purpose-in-life(+) were associated with cognition in early midlife.Smoking(-) was also associated with cognition in early midlife.Results were consistent controlling for genetic and environmental confounds.Association between EA and cognition might be mostly genetic and familial confounded.
Keywords: cognitive function; established adulthood; life course; lifestyle; modifiable risk factors; psychosocial; twin.
- Creator
- Date Issued
- 2024
- Academic Affiliation
- Journal Title
- Journal Issue/Number
- 3
- Journal Volume
- 16
- Last Modified
- 2024-10-30
- Resource Type
- Rights Statement
- DOI
- ISSN
- 2352-8729
- Language
- License
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Alz_Dem_Diag_Ass_Dis_Mo_-_2024_-_Zheng_-_Lifestyle_and_psychosocial_associations_with_cognition_at_the_cusp_of_midlife.pdf | 2024-10-30 | Public | Download |