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Jackson Heart Study: Aggregate cardiovascular disease risk and auditory profiles Public Deposited

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https://scholar.colorado.edu/concern/articles/4m90dw99d
Abstract

  • Objectives

    Evaluate the relationship between cardiovascular disease (CVD) risk factors and cochlear function in African Americans.

    Methods

    Relationships between hearing loss, cochlear function, and CVD risk factors were assessed in a cross-sectional analysis of 1106 Jackson Heart Study participants. Hearing loss was defined as puretone average (PTA0.5,1,2,4) > 15 dB HL. Distortion product otoacoustic emissions (DPOAEs) were collected for f2 = 1.0–8.0 kHz. Two amplitude averages were computed: DPOAElow (f2 ≤ 4 kHz) and DPOAEhigh (f2 ≥ 6 kHz). Based on major CVD risk factors (diabetes, current smoking, total cholesterol ≥240 mg/dL or treatment, and systolic blood pressure [BP]/diastolic BP ≥ 140/≥90 mmHg or treatment), four risk groups were created: 0, 1, 2, and ≥3 risk factors. Logistic regression estimated the odds of hearing loss and absent/reduced DPOAElow and DPOAEhigh by CVD risk status adjusting for age, sex, education, BMI, vertigo, and noise exposure.

    Results

    With multivariable adjustment, diabetes was associated with hearing loss (OR = 1.48 [95% CI: 1.04–2.10]). However, there was not a statistically significant relationship between CVD risk factors (individually or for overall risk) and DPOAEs.

    Conclusion

    Diabetes was associated with hearing loss. Neither individual CVD risk factors nor overall risk showed a relationship to cochlear dysfunction.

    Level of Evidence

    2b.

     

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Date Issued
  • 2023
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Last Modified
  • 2023-03-08
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  • 2378-8038
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