Article

 

On-chip Acousto Thermal Shift Assay for Rapid and Sensitive Assessment of Protein Thermodynamic Stability Public Deposited

https://scholar.colorado.edu/concern/articles/41687j57k
Abstract
  • In article number 2003506, Xiaoyun Ding and co‐workers present an acousto thermal shift assay (ATSA) utilizing acoustic mechanisms to denature proteins and concentrate protein precipitates for rapid and label‐free assessment of protein thermodynamic changes in real time. The whole process, including sample handling, protein unfolding, and measurement, takes place within a microfluidic chip in less than two minutes, and is faster than other current thermal shift assays.

Creator
Date Issued
  • 2020-10
Academic Affiliation
Journal Title
Journal Issue/Number
  • 41
Journal Volume
  • 16
Last Modified
  • 2020-11-13
Resource Type
Rights Statement
DOI
ISSN
  • 1613-6829
Language

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