Article

Abstract

• We recently initiated microcracks, i.e. micron-scale cracks in the collagen networks of cartilage, using both single low-energy impacts and unconfined, cyclic compressions. We also tracked the propagation of microcracks after cyclic compressions simulating 12,000 walking strides. In this study, we aimed to determine the effect of one or more genipin treatments on: (1) the initiation of microcracks under mechanical impacts and (2) the subsequent propagation of microcracks under cyclic, unconfined compression. We hypothesized that treatments with genipin would improve the resistance of cartilage to microdamage, specifically reducing both the initiation of microcracks under impact loading and the propagation of microcracks under cyclic compression.

Creator

• Neu, Corey P
• Pierce, David M.
• Grady, James J.
• Santos, Stephany

Date Issued

• 2022

Academic Affiliation

• College of Engineering and Applied Science

Journal Title

• Osteoarthritis and Cartilage Open Journal

Journal Issue/Number

• 1

Journal Volume

• 4

Last Modified

• 2024-11-17

Resource Type

• Article

Rights Statement

• In Copyright

DOI

•  https://doi.org/10.1016/j.ocarto.2022.100233

ISSN

• 2665-9131

Language

• English [eng]

License

• Creative Commons BY Attribution 4.0 International

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