Article
Loss of niche-satellite cell interactions in syndecan-3 null mice alters muscle progenitor cell homeostasis improving muscle regeneration. Pubblico Deposited
https://scholar.colorado.edu/concern/articles/0k225b644
- Abstract
- BACKGROUND: The skeletal muscle stem cell niche provides an environment that maintains quiescent satellite cells, required for skeletal muscle homeostasis and regeneration. Syndecan-3, a transmembrane proteoglycan expressed in satellite cells, supports communication with the niche, providing cell interactions and signals to maintain quiescent satellite cells. RESULTS: Syndecan-3 ablation unexpectedly improves regeneration in repeatedly injured muscle and in dystrophic mice, accompanied by the persistence of sublaminar and interstitial, proliferating myoblasts. Additionally, muscle aging is improved in syndecan-3 null mice. Since syndecan-3 null myofiber-associated satellite cells downregulate Pax7 and migrate away from the niche more readily than wild type cells, syxndecan-3 appears to regulate satellite cell homeostasis and satellite cell homing to the niche. CONCLUSIONS: Manipulating syndecan-3 provides a promising target for development of therapies to enhance muscle regeneration in muscular dystrophies and in aged muscle.
- Creator
- Date Issued
- 2016-01-01
- Academic Affiliation
- Journal Title
- Journal Volume
- 6
- File Extent
- 34-34
- Subject
- Ultima modifica
- 2019-12-05
- Identifier
- PubMed ID: 27757223
- Resource Type
- Dichiarazione dei diritti
- DOI
- ISSN
- 2044-5040
- Language
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lossOfNicheSatelliteCellInteractionsInSyndecan3NullMice.pdf | 2019-12-05 | Pubblico | Scaricare |