Authors

Clotilde Théry
Kenneth W Witwer
Elena Aikawa
Maria Jose Alcaraz
Johnathon D Anderson
Ramaroson Andriantsitohaina
Anna Antoniou
Tanina Arab
Fabienne Archer
Georgia K Atkin-Smith
D Craig Ayre
Jean-Marie Bach
Daniel Bachurski
Hossein Baharvand
Leonora Balaj
Shawn Baldacchino
Natalie N Bauer
Amy A Baxter
Mary Bebawy
Carla Beckham
Apolonija Bedina Zavec
Abderrahim Benmoussa
Anna C Berardi
Paolo Bergese
Ewa Bielska
Cherie Blenkiron
Sylwia Bobis-Wozowicz
Eric Boilard
Wilfrid Boireau
Antonella Bongiovanni
Francesc E Borràs
Steffi Bosch
Chantal M Boulanger
Xandra Breakefield
Andrew M Breglio
Meadhbh Á Brennan
David R Brigstock
Alain Brisson
Marike Ld Broekman
Jacqueline F Bromberg
Paulina Bryl-Górecka
Shilpa Buch
Amy H Buck
Dylan Burger
Sara Busatto
Dominik Buschmann
Benedetta Bussolati
Edit I Buzás
James Bryan Byrd
Giovanni Camussi
David Rf Carter
Sarah Caruso
Lawrence W Chamley
Yu-Ting Chang
Chihchen Chen
Shuai Chen
Lesley Cheng
Andrew R Chin
Aled Clayton
Stefano P Clerici
Alex Cocks
Emanuele Cocucci
Robert J Coffey
Anabela Cordeiro-da-Silva
Yvonne Couch
Frank Aw Coumans
Beth Coyle
Rossella Crescitelli
Miria Ferreira Criado
Crislyn D'Souza-Schorey
Saumya Das
Amrita Datta Chaudhuri
Paola de Candia
Eliezer F De Santana
Olivier De Wever
Hernando A Del Portillo
Tanguy Demaret
Sarah Deville
Andrew Devitt
Bert Dhondt
Dolores Di Vizio
Lothar C Dieterich
Vincenza Dolo
Ana Paula Dominguez Rubio
Massimo Dominici
Mauricio R Dourado
Tom Ap Driedonks
Filipe V Duarte
Heather M Duncan
Ramon M Eichenberger
Karin Ekström
Samir El Andaloussi
Celine Elie-Caille
Uta Erdbrügger
Juan M Falcón-Pérez
Farah Fatima
Jason E Fish
Miguel Flores-Bellver
András Försönits
Annie Frelet-Barrand
Fabia Fricke
Gregor Fuhrmann
Susanne Gabrielsson
Ana Gámez-Valero
Chris Gardiner
Kathrin Gärtner
Raphael Gaudin
Yong Song Gho
Bernd Giebel
Caroline Gilbert
Mario Gimona
Ilaria Giusti
Deborah Ci Goberdhan
André Görgens
Sharon M Gorski
David W Greening
Julia Christina Gross
Alice Gualerzi
Gopal N Gupta
Dakota Gustafson
Aase Handberg
Reka A Haraszti
Paul Harrison
Hargita Hegyesi
An Hendrix
Andrew F Hill
Fred H Hochberg
Karl F Hoffmann
Beth Holder
Harry Holthofer
Baharak Hosseinkhani
Guoku Hu
Yiyao Huang
Veronica Huber
Stuart Hunt
Ahmed Gamal-Eldin Ibrahim
Tsuneya Ikezu
Jameel M Inal
Mustafa Isin
Alena Ivanova
Hannah K Jackson
Soren Jacobsen
Steven M Jay
Muthuvel Jayachandran
Guido Jenster
Lanzhou Jiang
Suzanne M Johnson
Jennifer C Jones
Ambrose Jong
Tijana Jovanovic-Talisman
Stephanie Jung
Raghu Kalluri
Shin-Ichi Kano
Sukhbir Kaur
Yumi Kawamura
Evan T Keller
Delaram Khamari
Elena Khomyakova
Anastasia Khvorova
Peter Kierulf
Kwang Pyo Kim
Thomas Kislinger
Mikael Klingeborn
David J Klinke
Miroslaw Kornek
Maja M Kosanović
Árpád Ferenc Kovács
Eva-Maria Krämer-Albers
Susanne Krasemann
Mirja Krause
Igor V Kurochkin
Gina D Kusuma
Sören Kuypers
Saara Laitinen
Scott M Langevin
Lucia R Languino
Joanne Lannigan
Cecilia Lässer
Louise C Laurent
Gregory Lavieu
Elisa Lázaro-Ibáñez
Soazig Le Lay
Myung-Shin Lee
Yi Xin Fiona Lee
Debora S Lemos
Metka Lenassi
Aleksandra Leszczynska
Isaac Ts Li
Ke Liao
Sten F Libregts
Erzsebet Ligeti
Rebecca Lim
Sai Kiang Lim
Aija Linē
Karen Linnemannstöns
Alicia Llorente
Catherine A Lombard
Magdalena J Lorenowicz
Ákos M Lörincz
Jan Lötvall
Jason Lovett
Michelle C Lowry
Xavier Loyer
Quan Lu
Barbara Lukomska
Taral R Lunavat
Sybren Ln Maas
Harmeet Malhi
Antonio Marcilla
Jacopo Mariani
Javier Mariscal
Elena S Martens-Uzunova
Lorena Martin-Jaular
M Carmen Martinez
Vilma Regina Martins
Mathilde Mathieu
Suresh Mathivanan
Marco Maugeri
Lynda K McGinnis
Mark J McVey
David G Meckes
Katie L Meehan
Inge Mertens
Valentina R Minciacchi
Andreas Möller
Malene Møller Jørgensen
Aizea Morales-Kastresana
Jess Morhayim
François Mullier
Maurizio Muraca
Luca Musante
Veronika Mussack
Dillon C Muth
Kathryn H Myburgh
Tanbir Najrana
Muhammad Nawaz
Irina Nazarenko
Peter Nejsum
Christian Neri
Tommaso Neri
Rienk Nieuwland
Leonardo Nimrichter
John P Nolan
Esther Nm Nolte-'t Hoen
Nicole Noren Hooten
Lorraine O'Driscoll
Tina O'Grady
Ana O'Loghlen
Takahiro Ochiya
Martin Olivier
Alberto Ortiz
Luis A Ortiz
Xabier Osteikoetxea
Ole Østergaard
Matias Ostrowski
Jaesung Park
D Michiel Pegtel
Hector Peinado
Francesca Perut
Michael W Pfaffl
Donald G Phinney
Bartijn Ch Pieters
Ryan C Pink
David S Pisetsky
Elke Pogge von Strandmann
Iva Polakovicova
Ivan Kh Poon
Bonita H Powell
Ilaria Prada
Lynn Pulliam
Peter Quesenberry
Annalisa Radeghieri
Robert L Raffai
Stefania Raimondo
Janusz Rak
Marcel I Ramirez
Graça Raposo
Morsi S Rayyan
Neta Regev-Rudzki
Franz L Ricklefs
Paul D Robbins
David D Roberts
Silvia C Rodrigues
Eva Rohde
Sophie Rome
Kasper Ma Rouschop
Aurelia Rughetti
Ashley E Russell
Paula Saá
Susmita Sahoo
Edison Salas-Huenuleo
Catherine Sánchez
Julie A Saugstad
Meike J Saul
Raymond M Schiffelers
Raphael Schneider
Tine Hiorth Schøyen
Aaron Scott
Eriomina Shahaj
Shivani Sharma
Olga Shatnyeva
Faezeh Shekari
Ganesh Vilas Shelke
Ashok K Shetty
Kiyotaka Shiba
Pia R-M Siljander
Andreia M Silva
Agata Skowronek
Orman L Snyder
Rodrigo Pedro Soares
Barbara W Sódar
Carolina Soekmadji
Javier Sotillo
Philip D Stahl
Willem Stoorvogel
Shannon L Stott
Erwin F Strasser
Simon Swift
Hidetoshi Tahara
Muneesh Tewari
Kate Timms
Swasti Tiwari
Rochelle Tixeira
Mercedes Tkach
Wei Seong Toh
Richard Tomasini
Ana Claudia Torrecilhas
Juan Pablo Tosar
Vasilis Toxavidis
Lorena Urbanelli
Pieter Vader
Bas Wm van Balkom
Susanne G van der Grein
Jan Van Deun
Martijn Jc van Herwijnen
Kendall Van Keuren-Jensen
Guillaume van Niel
Martin E van Royen
Andre J van Wijnen
M Helena Vasconcelos
Ivan J Vechetti
Tiago D Veit
Laura J Vella
Émilie Velot
Frederik J Verweij
Beate Vestad
Jose L Viñas
Tamás Visnovitz
Krisztina V Vukman
Jessica Wahlgren
Dionysios C Watson
Marca Hm Wauben
Alissa Weaver
Jason P Webber
Viktoria Weber
Ann M Wehman
Daniel J Weiss
Joshua A Welsh
Sebastian Wendt
Asa M Wheelock
Zoltán Wiener
Leonie Witte
Joy Wolfram
Angeliki Xagorari
Patricia Xander
Jing Xu
Xiaomei Yan
María Yáñez-Mó
Hang Yin
Yuana Yuana
Valentina Zappulli
Jana Zarubova
Vytautas Žėkas
Jian-Ye Zhang
Zezhou Zhao
Lei Zheng
Alexander R Zheutlin
Antje M Zickler
Pascale Zimmermann
Angela M Zivkovic
Davide Zocco
Ewa K Zuba-Surma

Document Type

Article

Publication Date

1-1-2018

Publication Title

Journal of Extracellular Vesicles

ISSN

2001-3078

Volume

7

Issue

1

First Page

1535750

Last Page

1535750

DOI

https://doi.org/10.1080/20013078.2018.1535750

PubMed ID

30637094

Abstract

The last decade has seen a sharp increase in the number of scientific publications describing physiological and pathological functions of extracellular vesicles (EVs), a collective term covering various subtypes of cell-released, membranous structures, called exosomes, microvesicles, microparticles, ectosomes, oncosomes, apoptotic bodies, and many other names. However, specific issues arise when working with these entities, whose size and amount often make them difficult to obtain as relatively pure preparations, and to characterize properly. The International Society for Extracellular Vesicles (ISEV) proposed Minimal Information for Studies of Extracellular Vesicles ("MISEV") guidelines for the field in 2014. We now update these "MISEV2014" guidelines based on evolution of the collective knowledge in the last four years. An important point to consider is that ascribing a specific function to EVs in general, or to subtypes of EVs, requires reporting of specific information beyond mere description of function in a crude, potentially contaminated, and heterogeneous preparation. For example, claims that exosomes are endowed with exquisite and specific activities remain difficult to support experimentally, given our still limited knowledge of their specific molecular machineries of biogenesis and release, as compared with other biophysically similar EVs. The MISEV2018 guidelines include tables and outlines of suggested protocols and steps to follow to document specific EV-associated functional activities. Finally, a checklist is provided with summaries of key points.

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Creative Commons Attribution 4.0 License
This work is licensed under a Creative Commons Attribution 4.0 License.

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