Title
Nanoscale Reagents for the Detection and Treatment of Tuberculosis in Resource Limited Regions
Date of Award
Spring 1-1-2015
Document Type
Dissertation
Degree Name
Doctor of Philosophy (PhD)
Department
Chemistry & Biochemistry
First Advisor
Daniel Feldheim
Second Advisor
Theodore Randolph
Third Advisor
Gordana Dukovic
Fourth Advisor
Joel Eaves
Fifth Advisor
David Walba
Abstract
Tuberculosis (TB) remains the second deadliest infectious disease after HIV/AIDS. TB most stubbornly has been spreading in resource limited regions. People in these regions need diagnostics and therapeutics tailored to their available resources. Developing countries would best benefit from a diagnostic that is robust, gives quick results, and requires minimal electricity or materials. Likewise, a high impact therapeutic for these communities would promote patient compliance through oral administration and low toxicity. In this thesis work, these challenges are confronted by development of an orally bioavailable gold nanoparticle platform, a surface enhanced Raman spectroscopy assay for the detection of an TB biomarker in urine, and isolating modified-aptamers affinity reagents for the detection of TB biomarkers in urine.
Recommended Citation
Smith, Candice Ashley, "Nanoscale Reagents for the Detection and Treatment of Tuberculosis in Resource Limited Regions" (2015). Chemistry & Biochemistry Graduate Theses & Dissertations. 173.
https://scholar.colorado.edu/chem_gradetds/173
Included in
Animal Sciences Commons, Biochemistry Commons, Chemistry Commons