Article

 

Conserved RNA-binding specificity of polycomb repressive complex 2 is achieved by dispersed amino acid patches in EZH2. Public Deposited

https://scholar.colorado.edu/concern/articles/ks65hc86x
Abstract
  • Polycomb repressive complex 2 (PRC2) is a key chromatin modifier responsible for methylation of lysine 27 in histone H3. PRC2 has been shown to interact with thousands of RNA species in vivo, but understanding the physiological function of RNA binding has been hampered by the lack of separation-of-function mutants. Here, we use comprehensive mutagenesis and hydrogen deuterium exchange mass spectrometry (HDX-MS) to identify critical residues for RNA interaction in PRC2 core complexes from
Creator
Date Issued
  • 2017-11-29
Academic Affiliation
Journal Title
Journal Volume
  • 6
Subject
Last Modified
  • 2019-12-05
Identifier
  • PubMed ID: 29185984
Resource Type
Rights Statement
DOI
ISSN
  • 2050-084X
Language
License

Relationships

Items