Genes and Development
RNase P is the enzyme that removes 5′ leader sequences from precursor tRNAs. Remarkably, in most organisms, RNase P is a ribonucleoprotein particle where the RNA component is responsible for catalysis. In this issue of Genes & Development, Gutmann and colleagues (pp. 1022–1027) report the first organism,Arabidopsis thaliana, to employ protein-only RNase P in both its nucleus and organelles. An intriguing possibility is that replacement of RNase P ribonucleoprotein particles (RNPs) by proteins may have been triggered by the acquisition of organelles.
Goldfarb, Katherine C.; Borah, Sumit; and Cech, Thomas R., "RNase P Branches Out from RNP to Protein: Organelle-Triggered Diversification?" (2012). Chemistry & Biochemistry Faculty Contributions (1986-2018). 26.