Article

 

Intrinsically Disordered Regions Can Contribute Promiscuous Interactions to RNP Granule Assembly. Public Deposited

https://scholar.colorado.edu/concern/articles/v692t6791
Abstract
  • Eukaryotic cells contain large RNA-protein assemblies referred to as RNP granules, whose assembly is promoted by both traditional protein interactions and intrinsically disordered protein domains. Using RNP granules as an example, we provide evidence for an assembly mechanism of large cellular structures wherein specific protein-protein or protein-RNA interactions act together with promiscuous interactions of intrinsically disordered regions (IDRs). This synergistic assembly mechanism illuminates RNP granule assembly and explains why many components of RNP granules, and other large dynamic assemblies, contain IDRs linked to specific protein-protein or protein-RNA interaction modules. We suggest assemblies based on combinations of specific interactions and promiscuous IDRs are common features of eukaryotic cells.
Creator
Date Issued
  • 2018-02-06
Academic Affiliation
Journal Title
Journal Issue/Number
  • 6
Journal Volume
  • 22
File Extent
  • 1401-1412
Subject
Last Modified
  • 2019-12-05
Identifier
  • PubMed ID: 29425497
Resource Type
Rights Statement
DOI
ISSN
  • 2211-1247
Language
License

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