Document Type

Dissertation

Publication Date

Spring 5-24-1951

Abstract

Two histologically proven oases of eosinophilic granuloma limited to the lung are reported. The roentgen examination of the chest reveals a generalised granulomatous infiltrate throughout title lung fields with a background pattern of fibrosis and localised areas of emphysema. Clinically, these patients are almost asymptomatic in spite of the extensive radiographic changes in the lungs. The pathological examination of the surgical specimens obtained from these cases reveals a process identical to that found in the lesions of eosinophilic granuloma of the bone. One histologically proven case of eosinophilic granuloma of the bone with associated lung changes is reported. The roentgen examination of this patient’s chest reveals identical changes to those found in the first two cases. Although no pathological confirmation of the lung changes was obtained, it Is felt that this too represents a ease of eosinophilic granuloma of the lung. These lung lesions are identical to those found in the other members of xanthomatous group of diseases to which eosinophilic granuloma belongs. These also are identical to other oases reported in the literature of the lung lesions found in proven cases of eosinophilic granuloma of the bone. This is the first time that histological confirmation of the lung lesions has been reported. It is felt that the tern eosinophilic granuloma should he expanded to include those cases in which there are extra osseous lesions. It is suggested that these two cases of pulmonary eosinophilic granuloma are, like eosinophilic granuloma of the bone, the monosymptomatic form of a systemic xanthomatous disorder.

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