Document Type

Dissertation

Publication Date

Spring 5-26-1951

Abstract

The urinary corticoid excretion of patients suffering from dystrophia myotonioa, syotonia congenita, rheumatoid arthritis and disseminated lupus erythematosus was determined before, during and after hormonal therapy. The hormones administered were 17-hydroxy-11-dehydrocorticosteron, pregnenolone, dehydroisonandrosterone and the adrenoeorticotrophic hormone. The Corcoran and Page method was used to determine the excretory levels. In each of the three patients suffering from dystrophia myotonica whose excretory levels were determined during and after treatment with ACTH, a definite adrenal cortical response was noted. In five of the six patients suffering from dystrophia myotonlca and ayotonia congenita, an improvement in myotonia was realised. It is hoped from this evidence that the adrenocortlicotrophic hormone may offer some benefit in the treatment of these diseases. Two patients suffering from rheumatoid arthritis and one from disseminated lupus erythematosus showed no clinical response to treatment with massive doses of pregnenolone or dehyrdroisoandrosterone. However, in three of the four series involved, the pattern of corticoid excretion was similar to that noted when the adrenal cortex is under stress. It was postulated that the hormones might be converted into non-active corticoids or that they might produce a stress on the adrenal cortex.

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