Document Type

Dissertation

Publication Date

Fall 8-14-1961

Abstract

This study was done to evaluate the potentials of the utilization of glycerol for intravenous alimentation. A solution of twenty per cent glycerol in Ringer's lactate with Sorensen's phosphate buffer was administered to New Zealand White rabbits and adult mongrel dogs. Three rabbits received thirty consecutive daily glycerol infusions. Daily food and water intakes and urine volumes were recorded. Rectal temperatures were taken preinfusion and hourly postinfusion for six hours. A control group of three rabbits received Ringer's lactate with Sorensen's phosphate buffer. Weekly blood samples were obtained via cardiac puncture. At the completion of the study the rabbits were sacrificed and tissues obtained for histopathological studies. Three experiments were done using adult male mongrel dogs. Each dog received a single intravenous injection of twenty per cent glycerol in Ringer's lactate with Sorensen's phosphate buffer. The rate of infusion and volume of solution administered varied in the different studies. Blood and urine specimens were studied at thirty minute intervals to determine any changes caused by the glycerol injection.

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