Date of Award

Spring 1-1-2011

Document Type

Dissertation

Degree Name

Doctor of Philosophy (PhD)

Department

Chemistry & Biochemistry

First Advisor

R.E. Sievers

Second Advisor

Dan Feldheim

Third Advisor

Veronica Bierbaum

Abstract

Vaccination is frequently acknowledged as the invention most beneficial to human development. In the past 50 years vaccination has advanced greatly in terms of consistency and efficacy, but, in order to improve accessibility of vaccines to underserved populations in the developing world, more research must be conducted to improve the safety of delivery, affordability and stability of vaccines. This doctoral dissertation work has centered on the production of stable, dry powder vaccines and pharmaceuticals for inhalation. A principal goal has been to prepare consistent dry powders of measles vaccine for delivery by inhalation with activity comparable to commercially available products. Samples of vaccines received from collaborators at the Serum Institute of India have been analyzed and characterized to ensure consistency. This research has also uncovered a metastable crystal polymorph of myo-inositol (the primary excipient) as verified by powder X–ray diffraction and calorimetric studies. Research has also been conducted on the development and optimization of a dry powder, protein subunit Human Papillomavirus vaccine for delivery by inhalation, sublingual pellet or reconstitution for injection. One can hope that this research will lead to the advancement of vaccination and pulmonary delivered pharmaceutical powders, aiding in the reduction of global mortality and morbidity due to vaccine preventable disease.

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