Date of Award

Spring 1-1-2015

Document Type

Dissertation

Degree Name

Doctor of Philosophy (PhD)

Department

Chemistry & Biochemistry

First Advisor

Daniel Feldheim

Second Advisor

Theodore Randolph

Third Advisor

Gordana Dukovic

Fourth Advisor

Joel Eaves

Fifth Advisor

David Walba

Abstract

Tuberculosis (TB) remains the second deadliest infectious disease after HIV/AIDS. TB most stubbornly has been spreading in resource limited regions. People in these regions need diagnostics and therapeutics tailored to their available resources. Developing countries would best benefit from a diagnostic that is robust, gives quick results, and requires minimal electricity or materials. Likewise, a high impact therapeutic for these communities would promote patient compliance through oral administration and low toxicity. In this thesis work, these challenges are confronted by development of an orally bioavailable gold nanoparticle platform, a surface enhanced Raman spectroscopy assay for the detection of an TB biomarker in urine, and isolating modified-aptamers affinity reagents for the detection of TB biomarkers in urine.

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