Date of Award

Spring 1-1-2015

Document Type

Dissertation

Degree Name

Doctor of Philosophy (PhD)

Department

Chemistry & Biochemistry

First Advisor

Tarek H. Sammakia

Second Advisor

Maciej Walczak

Third Advisor

Xiang Wang

Fourth Advisor

Garret Miyake

Fifth Advisor

Peter Cogan

Abstract

While in the Sammakia Lab, I have focused on developing and applying new approaches to organic synthesis and the creation of novel cell-signaling inhibitors. My research efforts can be classified into (i) the development and application of new methods for the synthesis of novel chemical motifs, and (ii) the use of organic molecules as probes for problems in chemical biology. The use of the Lewis acid, ATNP, which promotes the vinylogous aldol reaction of enolizable aldehydes and ketones with furoate esters, and the design and synthesis of unnatural enantiomer morphinans as inhibitors of Toll-Like Receptor 4 will be discussed.

Included in

Biochemistry Commons

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