Document Type

Article

Publication Date

Winter 2-20-2009

Publication Title

Cell

Volume

136

Issue

4

First Page

599

Last Page

602

DOI

10.1016/j.cell.2009.02.002

Abstract

Comparison of phylogenetically diverse ribonucleoprotein (RNP) enzymes and information about their biochemistry have stimulated hypotheses about their evolution. Instead of the canonical view, in which catalysis proceeds from ribozyme to RNP enzyme to protein enzyme, RNP enzymes and proteins are seen to share contemporary catalysis. Furthermore, the RNA components of RNP enzymes show no evidence of fading out but instead, in some cases, have elaborated new functions.

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